R428 ( BGB324 )

Catalog No. M10189 CAS No. 1037624-75-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

R428
Note

Research use only, not for human use.
Brief Description

R428 (BGB324) is an inhibitor of Axl with IC50 of 14 nM.
Description

R428 (BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).
Synonyms

BGB324
Pathway

Tyrosine Kinase
Target

TAM Receptor
Recptor

AXL
Research Area

Cancer
Indication

——

CAS Number

1037624-75-1
Formula Weight

506.64
Molecular Formula

C30H34N8
Purity

>98%(HPLC)
Solubility

DMSO:24 mg/mL warmed (47.37 mM)Ethanol:<1 mg/mL (<1 mM)Water：<1 mg/mL (<1 mM)
SMILES

NC1=NC(NC2=CC=C3C(CC[C@@H](N4CCCC4)CC3)=C2)=NN1C5=NN=C6C(CCCC7=CC=CC=C76)=C5
Chemical Name

(S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine

1.Holland SJ, et al. Cancer Res, 2010, 70(4), 1544-1554.

Calculator

molnova catalog